Do you like your database and use it for most of your contacts/leads?

If you are generally happy with your database and use that one program to track a variety of contacts, even if from different campaigns etc. please let me know what database you're using and why. (History - we're only using Access and Excel and they're so un-user friendly we use a different one for each "list" or "campaign" so its a bit of a mess - want to figure out what to buy to consolidate...).